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Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 Randomized Clinical Trial

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Estrogen and progesterone, along with testosterone, may affect how sensitive your brain, pancreas, and metabolism are to GLP-1s effects on appetite regulation, blood sugar control, and energy balance

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Our Research Lead examined anonymized platform data from: 5,864 US adults using tirzepatide (Mounjaro or Zepbound) 4,456 US adults using semaglutide (Ozempic or Wegovy) Inclusion criteria: Active GLP-1 therapy with weekly injections Minimum 12-week tracking duration Adherence threshold: 1 injection log and 1 weight entry per week No weight entries outside physiological bounds (30300 kg) or with weekly changes exceeding 5% Primary outcome: Percentage body weight change from baseline, calculated as [(current weight baseline weight) / baseline weight] 100 , where negative values indicate weight loss Data collection period: Data were collected from all available platform records through January 2026, representing naturalistic use patterns without researcher intervention

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Journal Diabetes Investigation, 11 ,

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The Medication Version GLP-1 medications are synthetic versions of this hormone that work at higher levels than your body typically produces

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Alcohol tolerance changes on both medications

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