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Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice

Following PSM, a total of 7392 individuals were selected, corresponding to 1848 patients for each of the four study groups (GLP-1 receptor agonists, SGLT-2 inhibitors, insulin and miscellany groups) (Table 1)

In contrast to the case reports on altered renal function seen with exenatide, a pooled analysis of 5,594 participants from 19 randomized, controlled clinical trials of exenatide twice-daily (5 g and 10 g) showed that renal impairment-related adverse events, including acute renal failure, were rare (1.6 per 100 person-years for both groups)

Standards of Care in Diabetes 2020

doi: 10.2337/dbi20-0017 41 VolkeVKatusUJohannsonAToompereKHeinlaKRnkorgKet al

Medication without metabolic support is incomplete
