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The SUSTAIN 3 trial [168] (ClinicalTrials.gov identifier: NCT01885208) was a 56-week, open-label, parallel-group, randomized controlled trial of once-weekly semaglutide 1.0 mg subcutaneous with exenatide extended release 2.0 mg subcutaneous in patients with type 2 diabetes

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Importantly, tau monomers promote normal insulin signaling by inhibiting PTEN and thus inhibiting the conversion of PIP3 to PIP2, prolonging the activation of Akt/PKB (Fig

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