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The balancing of potential confounding variables was evaluated using standardised mean differences (SMD) with a threshold set a priori at 0.10

Moreover, potassium (K+) channels expressed in pancreatic -cells and peripheral insulin-sensitive tissues, which play a key role in glucose metabolism, are intensely modulated by carvedilol, establishing a link between K+ channels and the drugs effects on glucose control

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Immunohistochemistry was performed, as previously described (9, 24, 110)

As in prior experiments with GEP44, no indicators of nausea or malaise (e.g., changes in responsiveness, behavior, coat appearance, or facial expressions such as orbital tightening and nose/cheek flattening) were observed with GEP12 dosing

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