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GLP-1 receptor agonists improve MASH mostly via extrahepatic actions: 1 CNS appetite control weight loss systemic inflammation 2 Chylomicron synthesis & improve lipid metabolism 3 Bind gut immune cells anti-inflammatory + microbiome benefits 4 Reduce adipose & pancreatic inflammation

Quite a few celebrity men, including Andy Cohen and Jonathan Van Ness, have candidly admitted that they use GLP-1 drugs such as Ozempic for weight loss.

A relatively recent addition to the arsenal of antidiabetic drugs used for the treatment of type 2 diabetes mellitus (T2DM) has been the incretin mimetics, a group of drugs that work on the glucagon-like peptide-1 (GLP-1) receptor and enhance ...