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GLP-1R agonism could also improve BP via its ability to stimulate sodium excretion (natriuresis) via the kidneys [657]

Our protocol involves weekly administration under the skin of the upper leg (thigh), stomach area, or upper arm

In other words, GLP-1 therapy was tantalizing, but someone needed to figure out how one could extend the hormone's lifespan in the body long enough for it to be a viable drug

Appropriate management during the dose-escalation phase could help patients to develop tachyphylaxis, i.e., to avoid excessive delay in gastric emptying upon treatment with GLP-1 RAs, especially with the long-acting ones [37,38]