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Description
In the SURPASS-2 head-to-head against semaglutide for diabetes, tirzepatide produced significantly greater A1c reductions

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Although many treatments effective in animal models of IRI have failed to translate into clinical use, glucagon-like peptide 1 (GLP-1) and the GLP-1 receptor (GLP-1R) agonist exenatide have shown benefits in IRI in both animal models (47) and small early-phase clinical trials (8, 9)

PMID 9554326
doi: 10.1038/nm.3009
