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Effect on Metabolism and Fat Storage GLP-1s can improve insulin sensitivity, reduce inflammation, and encourage your body to burn more fat instead of storing it

Cardiovascular Outcomes Liraglutide (LEADER trial): 13% reduction in major adverse cardiovascular events (MACE) in patients with Type 2 diabetes and high cardiovascular risk Statistically significant cardiovascular protection Semaglutide (SELECT trial): 20% reduction in MACE in patients with obesity and established cardiovascular disease Studied specifically for cardiovascular outcomes in obesity (not just diabetes) Both medications provide cardiovascular protection, but semaglutides evidence is more recent, more robust, and specifically applicable to patients with obesity regardless of diabetes status

Semaglutide products were identified as suspect products for gallbladder-related disorders in these reports, finding 7,538 adverse reports for Ozempic

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PRAC concludes eye condition NAION is a very rare side effect of semaglutide medicines (Ozempic, Rybelsus, Wegovy)