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Heppner et al., 2015), and immunocytochemistry ( In vitro patch-clamp electrophysiological recordings revealed that modulating the electrophysiological properties of both POMC and cocaine- and amphetamine-regulated transcript (CART) neurons (POMC/CART neurons) and NPY/AgRP neurons are the possible mechanism of liraglutide-induced weight loss (Secher et al., 2014)

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But both drugs showed no weight loss plateau at their respective trial endpoints meaning neither has shown its ceiling yet