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10 Synthesis and future outlook: rediscovering dormant biology in the era of peptide engineering The cumulative evidence reviewed across metabolic, appetite-regulatory, bonemusclefat, neuroendocrine, and immunemetabolic peptide systems support a unifying conclusion: the apparent scarcity of transformative peptide therapeutics is not a consequence of limited biological opportunity, but rather of historical constraints in pharmacologic execution, translational strategy, and conceptual framing

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[DOI] [PubMed] [Google Scholar] [31].Holzapfel BM, Reichert JC, Schantz J-T, Gbureck U, Rackwitz L, Nth U, Jakob F, Rudert M, Groll J, Hutmacher DW, How smart do biomaterials need to be

12 Conclusion Several studies support the concept that SGLT2 inhibitors can be effective as adjuvant weight loss therapy when given together with agents that reduce food intake, and such combination treatments appear attractive

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Potential benefits: Research shows that tirzepatide leads to greater weight loss than semaglutidelikely because the two hormone mimickers work together for greater effects