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These include severe abdominal pain, persistent vomiting with inability to tolerate fluids, visual changes (especially for people with diabetes and existing retinopathy), signs of allergic reaction (rash, difficulty breathing, facial swelling), right upper quadrant pain with fever or jaundice (possible gallbladder disease), or symptoms of thyroid tumors (neck mass, hoarseness, difficulty swallowing)

Accessed 20 Jun 2022 Frias JP, Bonora E, Nevarez Ruiz L et al (2021) Efficacy and safety of dulaglutide 3.0 mg and 4.5 mg versus dulaglutide 1.5 mg in metformin-treated patients with type 2 diabetes in a randomized controlled trial (AWARD-11)

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Increased Ca2+ levels also promote transcription of the proinsulin gene, thereby increasing the insulin content of the cell

Likewise, adults who are married and get bariatric surgery are more than twice as likely to get divorced

Patients should not discontinue semaglutide without consulting their healthcare provider, as abrupt cessation may lead to deterioration in glycemic control or weight regain