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Compared with SGLT-2 inhibitor use, GLP-1 receptor agonist use was not associated with an increased risk of pulmonary aspiration (pooled risk ratio 0.98, 95% CI 0.73 to 1.31), although it was associated with a higher risk for discontinuation of endoscopy (1.99, 1.56 to 2.53)
Challenges with GLP-1 Therapy: Many users experience energy dips, muscle loss, and nutrient deficiencies while on GLP-1 therapies like semaglutide

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