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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Spinelli M, et al

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[12] demonstrated a low overall risk of bias, whereas the studies by Giagulli and Graybill [1, 11] were found to have a moderate risk of bias, primarily due to concerns related to outcome measurement and participant selection (Fig

For postpartum women with insulin resistance, PCOS, or gestational diabetes that persists after delivery, metformin may serve double duty by managing blood sugar and supporting weight loss

De hecho, los anlisis de mediacin realizados sugirieron que solo aproximadamente el 25% del beneficio sobre los resultados renales puede estar mediado por un mejor control glucmico y un 9-22% por los cambios sobre la presin arterial92,106, lo que sugiere el papel de mecanismos directos: reduccin de la hiperfiltracin, del estrs oxidativo y de la inflamacin, efectos antifibrticos, mejora de la disfuncin endotelial y/o posible reduccin de niveles de angiotensina ii52,54,107109