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The GCGR arm adds hepatic thermogenesis and lipolysis that tirzepatide does not generate

Triglycerides, which were elevated at baseline for most participants, drop an average of 28% by this point

It is not medical advice or a one-size-fits-all plan

Indeed GLP-1R agonists proved to be efficient for the treatment of type 2 diabetes mellitus 37 and studies indicate they could be used in other indications 26,43,44 such as obesity 45,46 , adverse cardiovascular events 25 , cognitive disorders 44 and non-alcoholic steatohepatitis (NASH) 47

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The gradual dose increase helps reduce side effects, particularly the common digestive issue, when starting treatment