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Collectively, these data support that CNS GIPR signalling has an important role in regulating energy metabolism and is an important target for anti-obesity medications

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Methodologically, among the included longitudinal studies, only 9 were double blind RCTs, 11 were open-label RCTs and 4 were non-randomized observational studies

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The efficacy and safety of second generation selective DPP4 inhibitors in the treatment of type 2 diabetes has been established