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Description

In addition to vascular protective effects, GLP-1R agonism improves experimental heart failure across several species, including mice (2132), rats (3337), pigs (38, 39), and dogs (40, 41) (Figure 2)

Serious side effects like pancreatitis or allergic reactions are rare

However, they carry different risks including genital infections and, rarely, diabetic ketoacidosis

Serious adverse effects requiring immediate medical attention include: Severe abdominal pain that may indicate pancreatitis (inflammation of the pancreas) Persistent nausea and vomiting leading to dehydration Changes in vision or eye pain (particularly in patients with type 2 diabetes and pre-existing retinopathy) Signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness) Symptoms of gallbladder disease (upper right abdominal pain, fever, jaundice) Severe allergic reactions (rash, difficulty breathing, swelling) These medications carry a boxed warning regarding thyroid C-cell tumors observed in rodent studies, though there is no definitive evidence of this risk in humans