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Enzymes and stomach acids break down proteins quickly, meaning only a tiny fraction of an oral dose is successfully absorbed into systemic circulation

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DPP4-Inhibitor Improves Neuronal Insulin Receptor Function, Brain Mitochondrial Function and Cognitive Function in Rats With Insulin Resistance Induced by High-Fat Diet Consumption

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All DPP4is share certain effects, referred to as class effects, that are directly linked to their mechanism of action

doi: 10.1038/s41386-019-0531-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 165.Lau D, Gamble JM