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Description
We showed that ER36 transcriptionally enhanced the expression of a key CSC marker ALDH1A1, which is a detoxifying enzyme participating in oxidation of intracellular aldehydes 31,57

Bossart M, Wagner M, Elvert R, Evers A, Hbschle T, Kloeckener T, et al

cAMP responses to exendin-4, with an intermediate pattern, were potentiated in arrestin-null cells, showing both increased potency and a trend toward higher efficacy over time compared to wild-type

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They adjust the dose to make sure it works well while keeping side effects low
