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The cargo hold of an airplane is not temperature controlled
That uncertainty is understandable
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However, in partial responders or those unable to escalate dose, future strategies may involve agents such as peripherally acting cannabinoid type 1 receptor antagonists, FGF21 analogs, amylin mimetics, or emerging triple agonists like retatrutide, which target GLP-1, GIP, and glucagon receptors simultaneously
This part of the guideline is silly because there is no way to risk stratify these patients using the stated risk factors
The observed changes in the biochemical markers in this study were similar but smaller in magnitude than reported in randomized trials
