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Description
Higher IGF-1 promotes: Lipolysis the breakdown of stored fat, particularly visceral fat Lean mass preservation reduced muscle catabolism Improved glucose metabolism better insulin sensitivity at the cellular level Enhanced lipid clearance lower triglycerides, improved lipid profiles Monitoring IGF-1 during tesamorelin therapy is not optional

Reconstitution: 2.0 mL per 10 mg vial (5.0 mg/mL) for manageable injection volumes

Cho YK, La Lee Y, Jung CH

Individual tolerance varies

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Pre-restart assessment should include: Review of the reason for discontinuation and whether it has been adequately addressed Current weight and glycemic status (if diabetic) Assessment of gastrointestinal symptoms and any contraindications Medication reconciliation to identify potential drug interactions For patients taking insulin or sulfonylureas, consider dose reductions to prevent hypoglycemia For women of childbearing potential using oral contraceptives, recommend backup contraception for 4 weeks after restarting and after each dose increase Discussion of realistic expectations and commitment to continued treatment Patient counseling is essential
