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By: Kristin Brooks Managing Editor, Contract Pharma Merck and Hansoh Pharma, a Chinese biopharmaceutical company, have entered into an exclusive global license agreement for HS-10535, an investigational preclinical oral small molecule GLP-1 receptor agonist

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Nonetheless, the mechanistic complementarityspanning vascular delivery, metabolic signaling, and mitochondrial efficiencyoffers a biologically plausible rationale for further investigation, particularly in early disease stages where restoring energy balance may yield the greatest protective effect

Evidence-Based Management First-line treatment for FM emphasizes nonpharmacologic strategies: aerobic exercise, yoga, sleep optimization, cognitive-behavioral approaches, and education