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Parallel fibrogenesis in the liver and myocardium adds to ventricular stiffness and diastolic dysfunction, while gut dysbiosis from a Western diet heightens systemic inflammation and endotoxemia, worsening cardiac and hepatic dysfunction

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During traditional dieting, the body responds to caloric deficit by increasing ghrelin (the hunger hormone), decreasing leptin (the satiety hormone), reducing thyroid hormone output, and increasing cortisol