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The GLP-1 receptors in the mesolimbic brain region are thought to help modulate reward behaviour

Tirzepatide has a higher affinity with GLP-1R than GLP-1 does (pIC 50 : 8.90 vs 8.62), and its cAMP activation activity is significantly lower (12 decrease in pEC 50 )

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The prespecified selection criteria included: (1) RCTs reporting desired cardiovascular or renal outcomes