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Acute overdose of phentermine may be associated with restlessness, tremor, hyperreflexia, rapid respiration, confusion, aggressiveness, hallucinations, and panic states

Advise patients not to abruptly stop phentermine and topiramate extended-release capsules without first talking to their health care provider(s) [see Dosage and Administration (2.3) and Warnings and Precautions (5.9)]

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