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The explanation for the discrepancy in the reduction of MACE in patients treated with SGLT2i in DECLARE-TIMI 58 suggests that the benefits of SGLT2i may be more pronounced in patients with a higher risk of cardiovascular disease

Brandt SJ, Mller TD, DiMarchi RD, Tschp MH, Stemmer K

Li Q, Tuo X, Li B, Deng Z, Qiu Y, Xie H

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Management of Hyperglycemia in Type 2 Diabetes, A consensus report by the american diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

278 Muscle, Adipose Tissue and Liver Given the ability of GLP-1 to promote the incretin effect, 11,107 this hormone has indirect actions on tissues such as skeletal muscle, adipose tissue and the liver through insulin- insulin acts as a second messenger of GLP-1