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In comparison, in GLP-1R the ECL1 consistently adopts a -helical conformation and the ECL1, ECL3 and stalk of the TMD all reorient to facilitate the binding of the peptide agonist

Methods 4 , 923925 (2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Aroda V.R., Bauer R., Christiansen E., Haluzk M., Kallenbach K., Montanya E., Rosenstock J., Meier J.J

The following data were obtained at baseline as well as three and six months (M3, M6) after initiation of the treatment with a GLP-1-RA + UCWM or UCWM alone: body weight, monthly headache days (MHD) recorded in a headache diary, and ophthalmological assessment including visual acuity, perimetry, fundoscopy, optical coherence tomography (OCT) and ocular ultrasonography

So you could consume what normally feels like a safe amount, yet end up more impaired than you realize

Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes