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A comprehensive search of PubMed, Scopus, CENTRAL, Web of Science, Embase, and ClinicalTrials.gov was conducted to identify relevant studies

Consider this post the context-setting for the 2026 Health Populi TrendCast which youll see next week

The decline comes as a growing number of Americans turn to GLP-1 drugs to lose weight.

Discover the evidence linking semaglutide to this digestive side effect, understand why it happens, and learn practical management strategies to reduce symptoms whilst continuing treatment.

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In absolute terms, the primary composite occurred in 0.7% of GLP-1 users and 1.8% of never-users during days 91365, corresponding to approximately one fewer event per 100 patients