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These authors concluded that the proportion of LBM relative to total body mass increased with semaglutide. Similarly, in the SURMOUNT-1 trial which studied tirzepatide, researchers found that participants treated with tirzepatide had a percent reduction in fat mass approximately 3 times greater than the reduction in lean mass, resulting in an overall improvement in body composition. More recently, a viewpoint in JAMA re-grounded the conversation: weight loss in persons with obesity primarily reduces body fat, but also decreases fat free mass (FFM)

Further studies will be needed to see if tirzepatide drugs, like Zepbound, also increase the risk of blood clots and DVT, which can lead to pulmonary embolisms

For people with Type 2 diabetes and obesity, weight loss often improves blood sugar levels and overall health

[DOI] [PubMed] [Google Scholar] 66.Gossmann M, Butsch WS, Jastreboff AM

Per Terms 16.2: "The Shed Promise is Shed's administrative commitment with respect to Shed Program Fees only

Lipoprotein effects of incretin analogs and dipeptidyl peptidase 4 inhibitors