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ONeilPMBirkenfeldALMcGowanBMosenzonOPedersenSDWhartonSet al
STEP-1 (NEJM 2021) established the weight-loss efficacy of semaglutide 2.4mg: 1,961 adults with obesity, mean 14.9% weight loss at 68 weeks versus 2.4% on placebo
Without careful dietary planning, this may result in a calorie deficit that compromises lean body mass
37 GLP-1 receptor activation in the hypothalamus and brainstem reduces appetite and enhances satiety
Most cases of constipation are mild to moderate and tend to improve as the body adjusts to the medication, typically within the first few weeks to months of treatment
Br J Pharmacol 2016;173:1820-34.ArticlePubMedPMC 48
