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Some brain imaging studies have demonstrated that depressed patients show neuronal atrophy and decreased volume of the cortex and limbic lobe regions, including the PFC and hippocampus

Specific GLP-1 receptor agonists (liraglutide, semaglutide, dulaglutide) have demonstrated cardiovascular benefits in clinical trials, including reduced risk of major adverse cardiovascular events

Dulaglutide reduces oxidative DNA damage and hypermethylation in the somatic cells of mice fed a highenergy diet by restoring redox balance, inflammatory responses, and DNA repair gene expressions

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This might mean documenting a trial of metformin, phentermine, or orlistat first

For example: Omega 1300 supports cholesterol balance and reduces triglycerides