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Researchers are continuing to study whether these side effects can be managed through dosing strategies

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During energy restriction, the body requires fuel and will mobilise stored reserves to meet its needs

Discard any unused reconstituted solution after this period

Lifestyle modifications that may help include wearing loose, soft-textured clothing made from natural fibers, using silk or satin bedsheets that produce less friction, maintaining a consistent room temperature to avoid thermal triggers, practicing stress reduction techniques since psychological stress can amplify central sensitization, and optimizing sleep hygiene since poor sleep worsens pain perception

Mood changes, such as an increase in anxiety, are also common during perimenopause, but berberine may positively affect mental health by improving gut bacteria