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GLP1 receptors are present in regions such as the nucleus accumbens and the ventral tegmental areakey nodes in the mesolimbic dopamine pathway

Lab Invest 94: 63-78, 2014

(C) Glp-1r / islets also secreted insulin in response to high glucose, but no potentiation was observed with GLP-1, OXM, or EX-4 treatment

The Institute for Health Metrics and Evaluation (IHME) estimates that high body mass index accounts for more than 160 million disability-adjusted life years globally, while diabetes prevalence continues to rise steadily, reinforcing demand for effective therapies like GLP-1 receptor agonists