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Based on data from Phase 2 clinical trials including the pivotal randomised controlled trial published in The New England Journal of Medicine in 2023 (Jastreboff et al.) the most frequently reported sensations and side effects with retatrutide are largely gastrointestinal (GI) in nature

Comparing GLP-1s can often feel the same way

doi: 10.1016/j.cmet.2018.03.001 Nauck MA, Meier JJ

Reflux is uncommon but can occur, especially in those with risk factors

Lifestyle Tips to Maximize Results with Semaglutide Follow a balanced, calorie-controlled diet

The native GLP-1 hormone your body produces has a half-life of only a few minutes