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doi: 10.3389/fmed.2022.875430 Summary Keywords glucagon-like peptide-1 receptor agonist (GLP-1RA), incretin based therapy, glucose-depent insulinotropic peptide (GIP), dual agonists, tirzepatide, type 2 diabetes Citation Gallwitz B (2022) Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity

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The strongest evidence base for mitigating fat-free mass loss during weight loss continues to favor nutrition and exercise prescriptions, particularly adequate protein intake and resistance training, rather than pharmacologic add-ons [3,4,38]

Krhus ML, Knudsen E, Knop FK

A few hours later, I opened my phone and started recording, sharing everything I just experienced in a semi-anesthesia drug-induced state

Especially regarding the central nervous system, the expression of GLP-1 receptors in reward-related regions, such as the hypothalamus, amygdala, nucleus accumbens, paraventricular nucleus, ventral tegmental area, locus coeruleus, and brain stem [21] may suggest a possible association between reward learning and symptoms like anhedonia in diseases such as depression