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[2] Central nervous system effects appear potentially relevant to understanding how these medications might influence binge eating patterns

To test whether hepatic CYP8B1 plays a primary role in the regulation of glucose metabolism by T3, we performed a CYP8B1-knockdown experiment using adeno-associated virus (AAV) expressing shRNA specific for Cyp8b1

Histological analysis revealed that mice treated with HORN-MN exhibited increased UCP1 protein expression in iWAT, along with reduced adipocyte size, indicating successful browning of white adipocytes

A pragmatic way forward is to (i) use Bayesian inference to express uncertainty in clinically interpretable probabilities, and (ii) use data-driven phenotyping (including ML-enabled clustering where appropriate) to describe heterogeneity in treatment response

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Treatment selection is individualized and based on medical history, therapeutic goals, tolerability, and provider guidance