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Understanding peptide receptor pharmacology clarifies how these seemingly contradictory effects balance in practice

GLP-1R agonist promotes proliferation of neuroendocrine neoplasm cells expressing GLP-1 receptors

Four structural regions were considered in our quest to improve GLP-1R agonist activity of small molecule 2 : the piperidine ring (yellow), the benzyl ether (green), the 5-fluoro-pyrimidine (blue), and the benzimidazole (red), as highlighted in Fig

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There are a lot of very interesting questions ahead of us. Drucker DJ

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