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[1] [2] Severe gastrointestinal adverse effects can lead to dehydration and acute kidney injury, particularly in patients with underlying renal impairment

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Among patients at high cardiovascular risk, the effect estimate was an HR of 0.88 (95% CI 0.73 to 1.07)

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Considering the findings that the activation of the GIP receptor increases adipose tissue blood flow and promotes adipose tissue lipid uptake, GIP receptor agonism in adipocytes may be a key regulator of postprandial lipid clearance and overall lipid homeostasis

Energy support during caloric restriction Fatigue is one of the most commonly reported side effects of tirzepatide therapy