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Oral administration is more likely to result in gastrointestinal adverse events, while subcutaneous injection is more likely to lead to endocrine system-related adverse events

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A 2019 study published in Diabetes Care (Frias et al.) examined the combination of semaglutide with an SGLT2 inhibitor and found additive reductions in both HbA1c and body weight compared to either medication used alone, with no significant increase in adverse events beyond what was expected from each medication individually

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Common Drug Interactions with GLP-1s Prescriptions to monitor include: Thyroid meds (like levothyroxine): delayed absorption = wonky labs Oral birth control : less reliable if not absorbed well (oops!) SSRIs/SNRIs : altered absorption can lead to mood changes Fat-soluble vitamins (A, D, E, K) : need bile flow and good digestion Iron/B12 : absorption requires stomach acid, which may be reduced PPIs (Prilosec, Nexium) : when combined with GLP-1s, can severely limit nutrient uptake Over-the-Counter Medications to Watch Even common OTC meds can cause problems when combined with GLP-1s

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