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What the 2025 Gastroenterology Metaanalysis Found The systematic review and metaanalysis (DOI: 10.1053/j.gastro.2025.06.003) evaluated safety outcomes across randomized trials and realworld studies of GLP1 RAs

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Moreover, bD-G1A and tD-G1A exhibited improved in vitro Caco-2 cellular permeability and showed higher in vivo bioavailability (7.58% and 8.63%) after oral administration
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In the subgroup analyses, human GLP-1 RAs, but not nonhuman GLP-1 RAs, reduced the risk of MACE in patients with HF (p interaction = 0.11)

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