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Slower titration schedules (e.g., starting at 0.25 mg weekly and increasing by 0.25 mg every 24 weeks) generally allow better GI adaptation than rapid escalation

Eating slowly and thoroughly chewing each bite

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Perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) and anti-neutrophil cytoplasmic autoantibodies (C-ANCA) were negative and ruled out the possibility of ANCA-associated vasculitis

Gastrointestinal effects are dose-related, meaning they generally plateau once you reach steady-state at 1 mg rather than worsening indefinitely