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Better weight control may be achieved if adequately intensive lifestyle changes are implemented and monitored in the T2D population treated with SGLT2is.

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Tirzepatide and injectable semaglutide were associated with the greatest weight loss after a year of treatment among several GLP-1 receptor agonists, a recent study showed.“Despite being the most recent medication approved for weight loss, tirzepatide [Zepbound, Eli Lilly] showed the greatest weight loss among the GLP-1 medications studied,&rdquo

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The companies said there is no risk to patients, while an investigation into the active pharmaceutical ingredient-related concern is underway.

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Among these, pioglitazone and liraglutide seem to improve some histological features of NASH but have no clear effect on fibrosis

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