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As GLP-1 therapies expand beyond diabetes and obesity, understanding their anti-inflammatory mechanisms may unlock new therapeutic uses

One randomized controlled trial of exenatide in patients with obesity and alcohol use disorder found trends toward reduced drinking, though results did not reach statistical significance in the primary outcome

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In 2014, Novos Saxenda (liraglutide) became the first GLP-1 agonist approved for obesity

In the EXSCEL (Exenatide Study of Cardiovascular Event Lowering) trial, Fudim et al

Headaches may recur briefly after dose increases but typically resolve with continued use and supportive measures like adequate hydration