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Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects without Diabetes and Patients with Type 2 Diabetes

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Animal and translational work hints at synergy between estrogen signaling and GLP-1 pathways, raising the possibility that fluctuating sex hormone states (menstrual cycle, menopause, exogenous hormones) may shape both efficacy and side-effect profiles (Vigil et al., 2022

Across studies with sufficient initial weight loss for meaningful interpretation, defined here as over 3 kg, the weight regained at or around 12 weeks post-cessation ranged from approximately 10 to 80% of the treatment-induced weight loss

Neuropharmacology (2013) 72:291300

Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells