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The reported indications for r-metHuLeptin therapy include leptin deficiency syndrome and lipodystrophic syndrome linked to inactivating mutations in the leptin gene, hypothalamic amenorrhea, lipodystrophic syndrome (genetic, acquired, or linked to HIV infection) and highly active antiretroviral therapy-induced lipoatrophy (Lee et al., There are few clinical reports on the effect of leptin therapy on diabetes

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