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1 The results will be presented later today at the 43 rd Annual J.P

patients, and clinical data showed no concerning safety patterns

While co-receptor targeting, as seen with AMG133, has shown promising results in weight reduction, it remains unclear whether this is an additive or synergistic effect, or if the main mode of action behind appetite suppression is based on GLP-1 receptor activation (104)

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Theres just one massive bottleneck: Oral bioavailability is lower than 5%