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In the CANVAS trial, canagliflozin was associated with an initial decrease in eGFR of 3.2ml/min compared to placebo but overall decreased change from baseline in eGFR compared to placebo at trial end.In a large meta-analysis, SGLTi medications reduced the progression of kidney disease by 37%

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Importantly, this gastric-emptying effect is most pronounced after initial doses and tends to diminish with continued use

If math is not your strength, that is perfectly fine

Symptoms can begin with increased heart rate, sweating, dizziness and irritability

It also incorporated quality-of-life assessments and cardiometabolic parameters, offering a holistic view of treatment impact
