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"When we stop these medications, especially, the hunger comes back very strongly, so there is a large association between stopping the medication and having that weight regain," says Dr

The results also add to a growing body of evidence supporting tirzepatide's position as a potentially best-in-class agent in its category, though the study's industry funding warrants consideration when interpreting the magnitude of the benefit

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The STEP UP Trial: Semaglutide Treatment Effect in People with Obesity The trial was a randomized, double-blind phase 3b study of 1,400 adults without type 2 diabetes that investigated a higher dose of Semaglutide (7.2 mg weekly) for weight management in adults with obesity

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