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Therefore, GLP-1RAs and GIP-RAs hold promise to be potential treatments for a wide variety of diseases

Sources Weight Regain and Cardiometabolic Effects After Withdrawal of Semaglutide: The STEP 1 Trial Extension Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity: SURMOUNT-4 PubMed Continued Treatment With Tirzepatide for Maintenance of Weight Reduction Wegovy Prescribing Information FDA Nutritional Priorities to Support GLP-1 Therapy for Obesity Dr

Nature 392 , 565568 (1998)

& Freedman, L

Other factors influencing GLP-1 secretion include activation of the olfactory receptor OR51E1 using nonanoic acid, which stimulates secretion of GLP-1 and PYY in human and rodent enteroendocrine L-cells [345]