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Currently, the approved GLP-1 agonists in the UK mimic GLP-1 (Wegovy and liraglutide), or both GLP-1 and GIP (Mounjaro)

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While SGLT2-i and GLP-1RA may offer additive or synergistic benefits in reducing BP and cardiovascular risk, current guidelines do not support their role as first-line antihypertensive agents or early adjunctive therapies over established agents such as thiazide diuretics, renin-angiotensin system (RAS) inhibitors, or calcium channel blockers (CCBs)

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Gene therapy for Parkinsons disease: trials and technical advances