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Hypokalemia: All insulin containing products can cause hypokalemia, which may be life-threatening

The pharmaceutical reason is straightforward: peptides are large protein molecules that require sufficient concentration to activate their target receptors on nerve cells and organs

Keywords Obesity GLP-1RA Eating disorder Atypical anorexia nervosa Bulimia nervosa Binge-eating disorder Cognitive behavior therapy Treatment Introduction Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of drugs initially approved for the treatment of type 2 diabetes

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At the highest doses, retatrutide seems to promise more significant weight loss than existing GLP-1s on the market but as dosage increases, so does the risk of side effects, mostly mild-to-moderate gastrointestinal issues, although one case of pancreatitis occurred in a patient on the 12mg dose during the phase II trial

Retatrutide extends that strategy to three receptors (GLP-1, GIP, glucagon)